SRscore - Simple Transcriptome Meta-Analysis for Identifying Stress-Responsive Genes

Stress Response score (SRscore) is a stress responsiveness measure for transcriptome datasets and is based on the vote-counting method. The SRscore is determined to evaluate and score genes on the basis of the consistency of the direction of their regulation (Up-regulation, Down-regulation, or No change) under stress conditions across multiple analyzed research projects. This package is based on the HN-score (score based on the ratio of gene expression between hypoxic and normoxic conditions) proposed by Tamura and Bono (2022) <doi:10.3390/life12071079>, and can calculate both the original method and an extended calculation method described in Fukuda et al. (2025) <doi:10.1093/plphys/kiaf105>.